RAF Typhoon jets have conducted a mission with French warplanes in a combined operation on an subterranean weapons facility in Syrian territory used by the IS group, according to the British defence ministry.
The facility, pinpointed through intelligence, was assessed as storing arms and explosives, the statement said, and was situated in hills just to the north of the ancient city of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to target a series of entry passages providing entry to the facility... preliminary assessments suggest the strike was effective," the MoD said.
There was no indication of any civilian impact in the strike on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager tanker plane.
Daesh - referred to as the so-called Islamic State - established militant control over parts of Syria and Iraq until 2019.
"This strike shows the UK's leading role, and determination to stand shoulder to shoulder with our allies, to stamp out any resurgence of Daesh and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the minister said.
RAF aircraft have conducted surveillance missions over Syrian airspace to "prevent any efforts to regroup" of the group following its military defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I must thank the personnel of our armed forces who took part in this mission for their professionalism and their bravery," the Defence Secretary added. "They were among a great many UK service members deployed over the festive period. This action, to eliminate dangerous terrorists who threaten our security, shows how our armed forces are ready to step up, all year round, ensuring Britain's security within its borders and powerful internationally."
In December, the American forces carried out what it described as a "large-scale strike" on IS targets in the country, subsequent to an assault claimed the lives of two US troops and a civilian interpreter in the Palmyra area.
The UN reports Daesh still boasts between 5,000 and 7,000 militants in Syria and Iraq.